Species differences in the response of liver drug metabolizing enzymes to EMD 392949 in vivo and in vitro
نویسندگان
چکیده
Laboratoire de Biologie Cellulaire, EA 3921, IFR 133, Faculté de Médecine et de Pharmacie, 25030 Besançon, France (L.R., A.B.) KaLy-Cell, Temis Innovation 18, rue Alain Savary, 25000 Besançon, France (L.R., C.V.-A., N.B.) Merck KGaA, Merck Serono, Non-Clinical Development, Toxicology, 64297 Darmstadt, Germany (G.T., S.O.M.) Merck KGaA, Merck Serono, Non-Clinical Development, DMPK, 85567 Grafing, Germany (E.W., H.D.) Service de Chirurgie Viscérale et Digestive Centre de Transplantation Hépatique, Hôpital Jean Minjoz, 25000 Besançon, France (B.H.) Service de Chirurgie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland (N.H.) DMD Fast Forward. Published on January 23, 2008 as doi:10.1124/dmd.107.018358
منابع مشابه
Species differences in the response of liver drug-metabolizing enzymes to (S)-4-O-tolylsulfanyl-2-(4-trifluormethyl-phenoxy)-butyric acid (EMD 392949) in vivo and in vitro.
Induction of drug-metabolizing enzymes (DMEs) is highly species-specific and can lead to drug-drug interaction and toxicities. In this series of studies we tested the species specificity of the antidiabetic drug development candidate and mixed peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist (S)-4-O-tolylsulfanyl-2-(4-trifluormethyl-phenoxy)-butyric acid (EMD 392949, EMD) w...
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